Pathologic Response of Primary Rectal Cancer to Oxaliplatin-Based Chemotherapy
نویسندگان
چکیده
منابع مشابه
A marker of homologous recombination predicts pathologic complete response to neoadjuvant chemotherapy in primary breast cancer.
PURPOSE To assess the prevalence of defective homologous recombination (HR)-based DNA repair in sporadic primary breast cancers, examine the clincopathologic features that correlate with defective HR and the relationship with neoadjuvant chemotherapy response. EXPERIMENTAL DESIGN We examined a cohort of 68 patients with sporadic primary breast cancer who received neoadjuvant anthracylcine-bas...
متن کاملOxaliplatin-Based Adjuvant Chemotherapy without Radiotherapy Can Improve the Survival of Locally-Advanced Rectal Cancer
OBJECTIVE To assess the impact of oxaliplatin-containing adjuvant chemotherapy on the survival of patients with locally-advanced rectal cancer. METHODS Data on patients with pathologically-confirmed T3/4 or N1/2 rectal cancer who accepted radical surgery at our center from January 2002 to June 2009 were reviewed retrospectively. The patients' 5-year overall survival (OS), disease-specific sur...
متن کاملsphincter preservation and pathologic response in rectal cancer undergoing neoadjuvant chemoradiation with and without oxaliplatin according to thymidilate synthase (ts) expression
background: oxaliplatin (ox) significantly enhanced the antitumor activity of 5-fu in patients with advanced colorectal cancer and recently some phase ii trials have evaluated the feasibility and efficacy of oxaliplatin in neoadjuvant setting for treatment of locally advanced rectal cancer. on the other hand various studies have demonstrated that the overexpression of thymidylate synthase (ts) ...
متن کاملComparison of 5FU-base Chemoradiation with and without Eloxatin on Pathologic Complete Response in Neoadjuvant Chemoradiation of Rectal cancer
Background and Objectives: To compare pathologic complete response (pCR) in patients with advanced rectal cancer receiving neoadjuvant chemoradiotherapy (NACT) by 5-FU or Xeloda (capecitabine) with and without Eloxatin (oxaloplatin injection). Materials and Methods: Seventy-five consecutive patients with the diagnosis of advanced rectal adenocarcinoma were included. Two basic chemotherapy r...
متن کاملMeta-analysis of oxaliplatin-based versus fluorouracil-based neoadjuvant chemoradiotherapy and adjuvant chemotherapy for locally advanced rectal cancer
A meta-analysis was conducted to compare oxaliplatin-based with fluorouracil-based neoadjuvant chemoradiotherapy and adjuvant chemotherapy for locally advanced rectal cancer. MEDLINE, EMBASE and CENTRAL were systematically searched for relevant randomized controlled trials (RCTs) until January 31 2017. Review Manager (version 5.3) was used to analyze the data. Dichotomous data were calculated b...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinics in Colon and Rectal Surgery
سال: 2011
ISSN: 1531-0043,1530-9681
DOI: 10.1055/s-0031-1278409